肌肉損傷和修復中的炎症過程

在10天的卸載期後以及隨後通過正常的自願行走重新加載24小時後，大鼠比目魚肌的橫截面。 免疫標記（抗ED2）並呈現紅褐色的非吞噬巨噬細胞分佈在肌纖維之間的整個結締組織中。 通常，非吞噬性巨噬細胞與重新加載的肌肉中的肌纖維表面緊密並置

新發現清楚地表明，在肌肉損傷或改良使用後，中性粒細胞很快就會促進肌肉損傷。 尚無直接證據表明中性粒細胞在肌肉修復或再生中發揮有益作用。 巨噬細胞也顯示出能夠通過釋放自由基在體內和體外促進肌肉損傷，儘管其他發現表明它們也可能通過生長因子和細胞因子介導的信號傳導在肌肉修復和再生中發揮作用。
新的證據還表明，肌細胞可以釋放炎症細胞侵襲的正調節劑和負調節劑，從而在調節炎症過程中發揮積極作用。

New findings clearly show a role for neutrophils in promoting muscle damage soon after muscle injury or modified use. No direct evidence is yet available to show that neutrophils play a beneficial role in muscle repair or regeneration. Macrophages have also been shown capable of promoting muscle damage in vivo and in vitro through the release of free radicals, although other findings indicate that they may also play a role in muscle repair and regeneration through growth factors and cytokine-mediated signaling. 
New evidence also shows that muscle cells can release positive and negative regulators of inflammatory cell invasion, and thereby play an active role in modulating the inflammatory process. 
Cross-sections of rat soleus muscle after a 10-day period of unloading and subsequent 24 h of reloading by normal, voluntary ambulation. Nonphagocytic macrophages that are immunolabeled (anti-ED2) and appear reddish-brown are distributed throughout the connective tissue between muscle fibers. Frequently, the nonphagocytic macrophages appear in close apposition to the surface of muscle fibers in the reloaded muscle


Tidball, James G. "Inflammatory processes in muscle injury and repair." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288.2 (2005): R345-R353.