韌帶和肌腱


高要求運動中經常發生肌肉損傷。科學文獻中沒有指南。 ISMuLT，“意大利肌肉，韌帶和肌腱協會”，根據其多學科使命，很自豪能夠彌補這一差距。

 9項隨機安慰劑對照試驗（n = 609）具有可接受的方法學質量，並在損傷或手術切口部位照射3個或更多點和/或超過2.5 cm2，總能量為5.0-19.5焦耳。 18項結果比較中，15項試驗結果顯示，LLLT組優於安慰劑組。差的和異構的數據呈現阻礙了連續數據的統計匯集
在固定效應模型中給出顯著的相對風險，改善2.7（95％置信區間[CI]，1.8-3.9）。結論：LLLT可以劑量依賴的方式調節炎症過程，並可以滴定，以顯著減少臨床環境中的急性炎症疼痛。
Muscle injuries are frequent in high demand sports. No guidelines are available in the scientific literature. ISMuLT, the “Italian Society of Muscles, Ligaments and Tendons”, in line with its multidisciplinary mission, is proud to cover this gap.
Nine randomized placebo-controlled trials (n = 609) were of acceptable methodological quality, and irradiated three or more points and/or more than 2.5 cm2 at site of injury or surgical incision, with a total energy of 5.0–19.5 Joules. Results in these nine trials were significantly in favor of LLLT groups over placebo groups in 15 out of 18 outcome comparisons. Poor and heterogeneous data presentation hampered statistical pooling of continuous data
giving a significant relative risk for improvement of 2.7 (95% confidence interval [CI], 1.8–3.9) in a fixed effects model. Conclusion: LLLT can modulate inflammatory processes in a dose-dependent manner and can be titrated to significantly reduce acute inflammatory pain in clinical settings. 

Bjordal, Jan Magnus, et al. "Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials." Photomedicine and Laser Therapy 24.2 (2006): 158-168.

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在高葡萄糖环境中对HGF具有抗炎作用

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仅在高葡萄糖培养基中培养的HGF显示出促炎细胞因子的显着高于与LLLI一起处理的那些。 然后我们观察到LLLI通过调节cAMP信号传导降低了在高葡萄糖培养基中培养的HGF中促炎细胞因子的表达。 我们还研究了抗氧化剂（维生素C）处理是否降低了在高葡萄糖培养基中培养的HGF中氧化应激的炎症效应，但是发现LLLI与LLLI共同处理没有添加效应，这表明LLLI可能激活cAMP信号传导，但不激活活性氧物质 （ROS）信号传导，以减少高葡萄糖诱导的炎症。 总之，LLLI可能在高葡萄糖环境中对HGF具有抗炎作用 HGFs cultured only in high-glucose medium showed significantly higher expression of pro-inflammatory cytokine than in those treated together with LLLI. We then observed that LLLI reduced the expression of pro-inflammatory cytokines in HGFs cultured in high-glucose medium by modulating cAMP signaling. We also investigated whether antioxidant (vitamin C) treatment reduced the inflammatory effect of oxidative stress in HGFs cultured in high-glucose medium but found no additive effect upon co-treatment with LLLI, suggesting that LLLI may activate cAMP signaling, but not reactive oxygen species (ROS) signaling, to reduce the high glucose-induced inflammation. In conclusion, LLLI may have an anti-inflammatory effect on HGFs in a high g...
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治療痙攣性腦癱

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在許多情況下，也觀察到不自主運動的加重和頸部和背部的疼痛。 現有的保守治療方法已證明或多或少無效，成人功能訓練的局限性使得治療極為困難。 我們在1994年首次採用低反應激光治療（LLLT）治療痙攣性腦癱，效果良好。 在本研究中，我們對20名患有成人緊張性手足徐動症的腦癱患者的肌無力嚴重的面部和頸部區域的所有肌強直部位應用激光照射（830 nm，60 mW連續波），但沒有效果 治療頸部和背部疼痛。 失眠和排尿困難也有所改善。 即使在最嚴重的情況下，協助患者變得更容易，呼吸也得到改善。 使用830 nm二極管激光器的LLLT在這個極其成問題的情況下提供了一種新的有效治療方式 Insomnia  and dysuria also improved. Even in the most severe cases, assisting the patient became easier and breathing improved.  LLLT  with the 830 nm diode laser provides a new and effective treatment modality in this extremely problematic condition, has no serious side   Aggravation of involuntary movements and pain in the neck and back are also seen in many cases. Existing conservative treatment methodologies have proved to be more or less ineffective, and limitations in functional training in adults have made treatment extremely difficult. We first employed low reactive-level laser therapy (LLLT) in a case of spastic cerebral palsy in 1994 with good results. In the presen...
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光耳廓療法

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該研究調查了三種微創手術，即激光耳廓療法（LAT），磁性耳廓療法（MAT）及其組合。使用了七個耳穴。治療每週進行三次，持續六週。在基線，六周和六週，三個月和六個月後的隨訪評估受試者。基於匹茲堡睡眠質量指數（PSQI），使用活動記錄監測的睡眠參數，使用SF-12的健康相關生活質量（HRQOL）和抑鬱症的PHQ-9，使用廣義估計方程來評估各組之間的相互作用。 三種方法的治療效果相當。隨著時間的推移，各個群體的所有主觀測量（PSQI，HRQOL和PHQ-9）均有顯著改善。在接受MAT程序但未接受LAT治療的受試者中檢測到使用活動記錄監測的客觀睡眠參數的改善。 This study investigated three minimally invasive procedures, namely, laser auriculotherapy (LAT), magneto-auriculotherapy (MAT), and their combination. Seven auricular points were used. Treatment was performed three times a week, for six weeks. Subjects were assessed at baseline, six weeks, and follow-up after six weeks, three months, and six months. Generalised estimating equations were used to evaluate interactions amongst the groups over time based on the Pittsburgh Sleep Quality Index (PSQI), sleep parameters using actigraphic monitoring, health-related quality of life (HRQOL) using SF-12, and PHQ-9 for depression status.  Results . The treatment effects of the three procedures were comparable. Si...
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