照射对高血糖条件下内皮细胞的影响

Góralczyk, Krzysztof, et al. "Low-level laser irradiation effect on endothelial cells under conditions of hyperglycemia." Lasers in medical science 31.5 (2016): 825-831.

Diabetes mellitus is considered to be a very serious lifestyle disease leading to cardiovascular complications and impaired wound healing observed in the diabetic foot syndrome. Chronic hyperglycemia is the source of the endothelial activation.
The LLLT—low-level laser therapy effectively supports the conventional treatment of diabetic vascular complications such as diabetic foot syndrome.
The aim of our study was to evaluate the effect of low-power laser irradiation at two wavelengths on the secretion of inflammatory factors—under conditions of hyperglycemia.
It leads to the reduction of TNF-α concentration in the supernatant and enhancement of cell proliferation. Endothelial cells play an important role in the pathogenesis of diabetes; however, a small number of studies evaluate an impact of LLLT on these cells under conditions of hyperglycemia.
The number of HUVEC cells depending on hyperglycemia and laser irradiation of different wavelengths. G glucose in culture medium, L(635) laser irradiation with wavelength of 635 nm, L(830) laser irradiation with wavelength of 830 nm.
糖尿病被认为是一种非常严重的生活方式疾病，导致糖尿病足综合症中观察到的心血管并发症和伤口愈合受损。慢性高血糖症是内皮激活的来源。
使用LLLT-低水平激光疗法有效地支持糖尿病足血管并发症如糖尿病足综合征的常规治疗。
研究目的是评估两种波长的低功率激光照射对炎症因子分泌的影响 - 在高血糖的条件。
它导致上清液中TNF-α浓度的降低和细胞增殖的增强。内皮细胞在糖尿病的发病机制中起重要作用。HUVEC细胞的数量取决于高血糖和不同波长的激光照射。 


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