膝關節炎

（A）控制 -  CG; （B）骨關節炎 -  OAC; （C）骨關節炎加運動訓練 -  OAT; （D）骨關節炎加LLLT  -  OAL; （E）骨關節炎加上與LLLT相關的運動訓練 -  OATL。


6週）減少疼痛，增加功能和肌肉力量...另外，低水平激光療法（LLLT）被認為是許多醫學病症的有前途的替代品...此外，一些作者證明LLLT能夠減少
所有治療組均顯示（照射或未照射）更好的組織組織模式，沿關節面和軟骨細胞組織的纖維化和不規則性較小，通過OARSI評分和較高的厚度值測量較低的退行性過程。 另外，與OAC相比，所有處理組在IL-1β，胱天蛋白酶-3和MMP-13中表達均降低。 此外，與OAL和OAT相比，在OATL中觀察到較低的胱天蛋白酶-3表達。 這些結果表明，運動訓練和LLLT可有效預防軟骨退變和調節膝關節炎引起的炎症過程。

6 weeks) decreased pain and increased functional capacity and muscle strength in … Additionally,
low-level laser therapy (LLLT) has been considered a promising alternative to many medical
conditions … Moreover, some authors demonstrated that LLLT was able of decreasing
All treated groups showed (irradiated or not) a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and chondrocytesorganization, a lower degenerative process measured by OARSI score and higher thickness values. Additionally, all treated group showed a reduced expression in IL-1β, caspase-3 and MMP-13compared to OAC. Moreover, a lower caspase-3 expression was observed in OATL compared to OAL and OAT. These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA.

Assis, L., et al. "Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats." Osteoarthritis and cartilage 24.1 (2016): 169-177.

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在高葡萄糖环境中对HGF具有抗炎作用

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仅在高葡萄糖培养基中培养的HGF显示出促炎细胞因子的显着高于与LLLI一起处理的那些。 然后我们观察到LLLI通过调节cAMP信号传导降低了在高葡萄糖培养基中培养的HGF中促炎细胞因子的表达。 我们还研究了抗氧化剂（维生素C）处理是否降低了在高葡萄糖培养基中培养的HGF中氧化应激的炎症效应，但是发现LLLI与LLLI共同处理没有添加效应，这表明LLLI可能激活cAMP信号传导，但不激活活性氧物质 （ROS）信号传导，以减少高葡萄糖诱导的炎症。 总之，LLLI可能在高葡萄糖环境中对HGF具有抗炎作用 HGFs cultured only in high-glucose medium showed significantly higher expression of pro-inflammatory cytokine than in those treated together with LLLI. We then observed that LLLI reduced the expression of pro-inflammatory cytokines in HGFs cultured in high-glucose medium by modulating cAMP signaling. We also investigated whether antioxidant (vitamin C) treatment reduced the inflammatory effect of oxidative stress in HGFs cultured in high-glucose medium but found no additive effect upon co-treatment with LLLI, suggesting that LLLI may activate cAMP signaling, but not reactive oxygen species (ROS) signaling, to reduce the high glucose-induced inflammation. In conclusion, LLLI may have an anti-inflammatory effect on HGFs in a high g...
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治療痙攣性腦癱

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在許多情況下，也觀察到不自主運動的加重和頸部和背部的疼痛。 現有的保守治療方法已證明或多或少無效，成人功能訓練的局限性使得治療極為困難。 我們在1994年首次採用低反應激光治療（LLLT）治療痙攣性腦癱，效果良好。 在本研究中，我們對20名患有成人緊張性手足徐動症的腦癱患者的肌無力嚴重的面部和頸部區域的所有肌強直部位應用激光照射（830 nm，60 mW連續波），但沒有效果 治療頸部和背部疼痛。 失眠和排尿困難也有所改善。 即使在最嚴重的情況下，協助患者變得更容易，呼吸也得到改善。 使用830 nm二極管激光器的LLLT在這個極其成問題的情況下提供了一種新的有效治療方式 Insomnia  and dysuria also improved. Even in the most severe cases, assisting the patient became easier and breathing improved.  LLLT  with the 830 nm diode laser provides a new and effective treatment modality in this extremely problematic condition, has no serious side   Aggravation of involuntary movements and pain in the neck and back are also seen in many cases. Existing conservative treatment methodologies have proved to be more or less ineffective, and limitations in functional training in adults have made treatment extremely difficult. We first employed low reactive-level laser therapy (LLLT) in a case of spastic cerebral palsy in 1994 with good results. In the presen...
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光耳廓療法

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該研究調查了三種微創手術，即激光耳廓療法（LAT），磁性耳廓療法（MAT）及其組合。使用了七個耳穴。治療每週進行三次，持續六週。在基線，六周和六週，三個月和六個月後的隨訪評估受試者。基於匹茲堡睡眠質量指數（PSQI），使用活動記錄監測的睡眠參數，使用SF-12的健康相關生活質量（HRQOL）和抑鬱症的PHQ-9，使用廣義估計方程來評估各組之間的相互作用。 三種方法的治療效果相當。隨著時間的推移，各個群體的所有主觀測量（PSQI，HRQOL和PHQ-9）均有顯著改善。在接受MAT程序但未接受LAT治療的受試者中檢測到使用活動記錄監測的客觀睡眠參數的改善。 This study investigated three minimally invasive procedures, namely, laser auriculotherapy (LAT), magneto-auriculotherapy (MAT), and their combination. Seven auricular points were used. Treatment was performed three times a week, for six weeks. Subjects were assessed at baseline, six weeks, and follow-up after six weeks, three months, and six months. Generalised estimating equations were used to evaluate interactions amongst the groups over time based on the Pittsburgh Sleep Quality Index (PSQI), sleep parameters using actigraphic monitoring, health-related quality of life (HRQOL) using SF-12, and PHQ-9 for depression status.  Results . The treatment effects of the three procedures were comparable. Si...
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