輕、中度和重度癌症疼痛的治療


遵循ESMO指南進行疼痛評估和治療可以對輕度，中度和重度癌症疼痛的治療有顯著幫助[18]。 低水平激光治療是一種廣泛發展的策略，用作癌症患者的輔助治療。 LLLT減輕疼痛（嚴重程度，強度和持續時間），炎症，腫脹，淋巴水腫，與放療和化療相關的疼痛相關的不良反應，如粘膜炎疼痛和皮膚病學病理，並具有鎮痛，抗炎和生物刺激作用[19-21]。 LLLT最初在表皮神經網絡水平具有直接作用，然後移動到皮下組織的神經

Following the ESMO-guidelines for pain assessment and treatment could of significant help in management of mild, moderate, and severe cancer pain [18]. Low-level laser therapy is a widely evolving strategy used as an adjunct therapy in cancer patients. LLLT reduces the pain (severity, intensity, and duration), inflammation, swelling, lymphedema, and adverse effects related pain of radiotherapy and chemotherapy such as pain in mucositis and dermatological pathologies in patients and have analgesic, anti-inflammatory and bio stimulating effects [19-21]. LLLT initially has a direct effect at the epidermal neural network level and then moves to the nerves in subcutaneous tissues

Vernucci, E., S. Agrawal, and V. Rai. "Role of Multidisciplinary Approach in the Management of Cancer Pain." Ann Psychiatr Clin Neurosci. 2018; 1 (1) 1005.

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在高葡萄糖环境中对HGF具有抗炎作用

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仅在高葡萄糖培养基中培养的HGF显示出促炎细胞因子的显着高于与LLLI一起处理的那些。 然后我们观察到LLLI通过调节cAMP信号传导降低了在高葡萄糖培养基中培养的HGF中促炎细胞因子的表达。 我们还研究了抗氧化剂（维生素C）处理是否降低了在高葡萄糖培养基中培养的HGF中氧化应激的炎症效应，但是发现LLLI与LLLI共同处理没有添加效应，这表明LLLI可能激活cAMP信号传导，但不激活活性氧物质 （ROS）信号传导，以减少高葡萄糖诱导的炎症。 总之，LLLI可能在高葡萄糖环境中对HGF具有抗炎作用 HGFs cultured only in high-glucose medium showed significantly higher expression of pro-inflammatory cytokine than in those treated together with LLLI. We then observed that LLLI reduced the expression of pro-inflammatory cytokines in HGFs cultured in high-glucose medium by modulating cAMP signaling. We also investigated whether antioxidant (vitamin C) treatment reduced the inflammatory effect of oxidative stress in HGFs cultured in high-glucose medium but found no additive effect upon co-treatment with LLLI, suggesting that LLLI may activate cAMP signaling, but not reactive oxygen species (ROS) signaling, to reduce the high glucose-induced inflammation. In conclusion, LLLI may have an anti-inflammatory effect on HGFs in a high g...
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治療痙攣性腦癱

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